This year the JEDNs are pleased to welcome:
Prof. Dr. Hans Clevers is a Principal Invistigator at the Hubrecht Insitute and the Princess Máxima Center for Pediatric Oncology in Utrecht in Netherlands. Clevers uncovered how Wnt signals control gene expression, i.e. through the interaction of Tcf transcription factors with the Wnt effector β-catenin. Looking beyond embryogenesis, he unveiled the role of Wnt signaling in colon cancer and in its physiological counterpart, the self-renewing gut epithelium. Combining these insights, he described the generic marker gene Lgr5, which has identified multiple novel adult stem cell types. Against prevailing views, these stem cells could be expanded indefinitely as organoids: mini-organs recapitulating healthy or diseased human tissue in a dish. Organoids are now widely used in basic and applied biomedicine, occupying a niche between ‘classical’ 2D cell lines and experimental animals.
Prof. Dr. Volker Haucke is a Full professor of Molecular Pharmacology, he’s also the head of the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) in Berlin. He and his team are working to understand how cell membranes and membrane-enclosed compartments dynamically exchange materials with each other and what the implications are for cell signalling in health and disease. The overarching goal of these studies is to provide a mechanistic understanding of the assembly of protein-lipid scaffolds that support exo-endocytosis coupling and endolysosomal functions, and to use this know-how to develop novel strategies for pharmacological or genetic interference.
You can fin the abstract of the presentations by clicking here.