Post-doctoral position on antiviral innate immunity in Drosophila in Jean-Luc Imler’s Lab (IBMC-UPR9022 Strasbourg)

A post-doctoral position funded by Agence Nationale de la Recherche (ANR)
is available to study the function of the cGAS/STING innate immunity pathway in the
model organism Drosophila melanogaster. Activation of this pathway in mammals
plays a critical role in the induction of interferons, with beneficial (immunotherapy,
vaccine adjuvant) and detrimental (interferonopathies) consequences. In the course
of an unbiased genetic analysis in Drosophila, we have recently established that in
this insect model devoid of interferon and IRF transcription factors, a STING
homologue has strong antiviral effect against some RNA viruses. The goal of the
project is to understand the mechanisms involved in this novel function of STING.

The position is for a period of three years and is available immediately. The
applicants must have expertise in one or two of the following areas: drosophila
genetics; molecular virology; cellular fractionation and biochemistry; live cell
imaging; RNA biology.

The selected applicant will join a multinational team composed of fifteen
people, hosted by the Institut de Biologie Moléculaire et Cellulaire (CNRS) on the
central campus of the University of Strasbourg (http://ibmc-ridi.cnrs.fr/en/researchgroups/
antiviral-immunity/). Enquiries/applications should be made by e-mail in the
form of a CV, a letter of motivation and the names and addresses of three references
to Inès Wernert (i.wernert@ibmc-cnrs.unistra.fr).