Job opportunities

Post doctoral position on pancreas development and stem cells in the German Centre for Diabetes Research in Dresden

A post-doctoral position is available in the research group of Dr Anthony Gavalas. The group investigates the role of signaling pathways and metabolism in the late stages of endocrine pancreas development, the application of novel signals for the conversion of human pluripotent stem cells into functional beta cells and the function of adult pancreas stem cells. A combination of directed pluripotent stem cell differentiation, genomics, in vivo genetic analyses and ex vivo experiments using explants and organoids is being used. (https://www.digs-bb.de/research/research-groups/anthony-gavalas/). The post-doctoral fellow is primarily required for a project that focuses on the manipulation of signaling pathways for the efficient conversion of human pluripotent stem cells into fully functional beta cells. However, depending on prior experience, projects on the metabolic regulation of endocrine pancreas development and newly identified adult pancreas stem cells may also be available. The successful candidate will have a Ph.D. degree in Biology or related disciplines, a good publication record and extensive experience in cell culture and differentiation of human pluripotent stem cells. Experience with CRISPRCas9 mediated genome engineering will be an asset. The lab is located in the Center for Regenerative Therapies Dresden (CRTD) with full access to state of the art core facilities for Deep Sequencing, including single cell RNA Seq, Genome Engineering, Imaging and FACS analysis. The salary will be according to the TV-L scale commensurate with experience and qualifications. The contract will be initially for two years with the possibility for renewal. Applicants are requested to send their CVs along with names Continuer la lecture Post doctoral position on pancreas development and stem cells in the German Centre for Diabetes Research in Dresden

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2 postdocs positions on ERC funded project @FendtLab

We (Laboratory for Cellular Metabolism and Metabolic Regulation; Fendt Lab) are a young and dynamic team of researchers performing cutting edge cancer metabolism research with special focus on cancer metastasis and novel metabolic pathways. We exploit in vivo mouse models, metabolomics and 13C tracer analysis to gain groundbreaking insights into metabolism as a driving force of cancer progression. Our work is published in high profile journals such as Nature, Nature Communications, Cell Reports, and Nature Immunology. We have a strong international recognition and top collaboration partners all over the world. PROFILE 1ST POSTDOC Are you interested in the metabolism of cancer cells metastasizing to different organs? You have a background in metabolism research or cancer metastasis. You have a strong in vivo expertise on cancer mouse models, you have successfully applied state-of-the-art genetic engineering technologies (such as CRISPR/CAS9), and you are an expert in molecular biology techniques including but not limited to western blot, qPCR, FACS, immunohistochemistry (IHC), and cell culture techniques. Expertise in tumor microenvironment research and/or immunology is a plus. You are interested in mass spectrometry and in vivo metabolism research. You like taking the scientific and experimental lead on a challenging project. You can work independently but also like to collaborate within the team and other research groups. You aim for high impact. 2ND POSTDOC Are you interested in novel metabolic pathways promoting cancer? You have a background in metabolism or cancer research. You have a strong expertise in dissecting regulatory mechanisms and translating your findings to Continuer la lecture 2 postdocs positions on ERC funded project @FendtLab

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‘Gene Expression’ Tenure Track/Associate Professorship position in Aarhus, Denmark

The Department of Molecular Biology and Genetics, Aarhus University invites applications to a position in the area of Gene Expression Biology to begin August 2018. Candidates for a Tenure Track position or an Associate Professorship are encouraged to apply.   The position As an assistant professor in a tenure-track position the candidate is expected to develop a strong and competitive research program and will be offered local mentoring during the tenure track period. Start-up funds to establish a competitive research program are negotiable. In case of more senior applicants, a position as associate professor will be considered.   The candidate Candidates pursuing internationally recognized research in Gene Expression Biology (e.g. Transcription, RNA metabolism or related areas) are encouraged to apply. We also welcome applicants practicing systems biology approaches. The successful candidate is expected to complement existing strengths of the Department, to contribute to Departmental activities and to engage in scientific interaction with academic staff. The candidate must have earned a Ph.D. degree and have demonstrated excellence in research and scholarship within the field of interest.   Successful candidates will be expected to: ‐ establish and lead their own research team ‐ deliver innovative research of the highest international standard ‐ deliver high quality teaching (associate professor level) ‐ supervise masters and PhD students ‐ complete postgraduate teacher training for Assistant Professors at Aarhus University (tenure track level). ‐ obtain competitive research funding from external funding bodies ‐ write and speak English fluently   The Department of Molecular Biology and Genetics Continuer la lecture ‘Gene Expression’ Tenure Track/Associate Professorship position in Aarhus, Denmark

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Post-doctoral position to work on ER stress signaling and neurodegeneration in the Univsersity of Chile

The Biomedical Neuroscience Institute (www.bni.cl) and the Geroscience Center for Brain Health and Metabolism (www.gerochile.cl) are seeking a highly-qualified and motivated applicant for a full time postdoctoral position at the laboratory of Proteostasis Control and Biomedicine of the University of Chile Post-Doc Position: This position funded by national grants project for a 2 to 3 year period. Starting date: March  2018 or upon agreement. Project:  The project is part of a larger initiative involving collaboration with different labs in the US, Europe and Chile. This laboratory focuses on understanding the molecular basis of proteostasis control and its relationship to pathological conditions affecting the nervous system. The project aims to the study cellular strategies involved in adaptation to chronic endoplasmic reticulum (ER) stress. The ER has important cellular functions, highlighting its role as sophisticated machinery for protein folding and secretion. ER stress engages an integrated signaling pathway known as the “Unfolded Protein Response” (UPR), which aims to restore homeostasis. Nevertheless, the mechanisms that control the transition from an adaptive state to cell death processes remain unknown and is a central subject of our research. We are currently developing a systematic approach to underscore the effects of targeting the UPR in several brain diseases. He/she investigates signal transduction pathways regulating stress pathways (UPR, autophagy and apoptosis). Furthermore, he/she supports the Chair in teaching and student supervision. Qualifications: Candidates are expected to hold a PhD in Biology or similar education, preferentially with several years of experience. Furthermore, a strong practical and theoretical background Continuer la lecture Post-doctoral position to work on ER stress signaling and neurodegeneration in the Univsersity of Chile

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Post-doctoral position on antiviral innate immunity in Drosophila in Jean-Luc Imler’s Lab (IBMC-UPR9022 Strasbourg)

A post-doctoral position funded by Agence Nationale de la Recherche (ANR) is available to study the function of the cGAS/STING innate immunity pathway in the model organism Drosophila melanogaster. Activation of this pathway in mammals plays a critical role in the induction of interferons, with beneficial (immunotherapy, vaccine adjuvant) and detrimental (interferonopathies) consequences. In the course of an unbiased genetic analysis in Drosophila, we have recently established that in this insect model devoid of interferon and IRF transcription factors, a STING homologue has strong antiviral effect against some RNA viruses. The goal of the project is to understand the mechanisms involved in this novel function of STING. The position is for a period of three years and is available immediately. The applicants must have expertise in one or two of the following areas: drosophila genetics; molecular virology; cellular fractionation and biochemistry; live cell imaging; RNA biology. The selected applicant will join a multinational team composed of fifteen people, hosted by the Institut de Biologie Moléculaire et Cellulaire (CNRS) on the central campus of the University of Strasbourg (http://ibmc-ridi.cnrs.fr/en/researchgroups/ antiviral-immunity/). Enquiries/applications should be made by e-mail in the form of a CV, a letter of motivation and the names and addresses of three references to Inès Wernert (i.wernert@ibmc-cnrs.unistra.fr).

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Postdoc Position in Epitranscriptomics (m6A mRNA methylation)

We are looking for a highly motivated Postdoc with a deep interest in epitranscriptomics to join our molecular genetics Drosophila research group in the School of Biosciences, University of Birmingham, UK to follow up on our findings published recently in Nature (Haussmann et al, 2016). Our laboratory is interested in resolving the function of m6A mRNA methylation in the regulation gene expression. We are applying a combination of state of the art genetic and molecular tools in a Drosophila genetic model complemented by in vitro molecular biology assays to understand how methylation sites are selected and how methylation levels are determined. Applicants must hold a PhD degree in biology and have extensive experience in molecular biology. Previous experience in Drosophila genetics or other genetic model systems would be appreciated. This BBSRC funded fixed–‐term appointment is available for 36 months starting in 2018. Starting salary is in the range of £28,982 to £40,082. To apply, please go to http://www.jobs.ac.uk/job/BGH859/research–‐fellow (Ref 58446) before 7. January 2017. Applications should include a full CV, a one page personal statement and contact details for at least two referees. For informal enquiries please contact Dr Matthias Soller (m.soller@bham.ac.uk)

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Postdoc Position Adrenal tissue homeostasis and cancer at the iBV, Nice, France

The Institute of Biologie Valrose (iBV) is a centre of excellence funded by Inserm, the CNRS and the University of Nice. The iBVs remit is to unravel the basic principles governing organism development and identifying the molecular basis of disease. Our team is interested in signalling pathways that ensure proper organ formation and tissue maintenance and their links with cancer. Further information on the research topics of the Schedl team can be found at http://ibv.unice.fr/EN/equipe/schedl.php. Applications are invited for a postdoctoral research fellow to work on adrenal tissue renewal, the balance of cell proliferation and apoptosis and the pathways that lead to adrenocortical cancer. You will perform in vitro, ex vivo and in vivo experiments and analyse mouse model systems on the phenotypic, molecular and genomic level. You will be working in an international research environment and benefit from state of the art equipment. The initial contract will be for a period of 36 months. The ideal candidate will be highly motivated, have a PhD degree in biological or biomedical sciences and good English communication and interpersonal skills. A background in developmental/stem cell biology/mouse genetics is an advantage. Andreas Schedl iBV, University of Nice Parc Valrose 06108 Nice, France For further information please visit our web site (ibv.unice.fr) and/or send an e-mail to schedl@unice.fr.

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1 poste d’assistant ingénieur/ingénieur à Nice

Le Centre Antoine Lacassagne (Nice) et les équipes du Dr Ellen Van Obberghen (iBV, Nice) et du Dr Fabienne Anjuère (IPMC, Valbonne) ont mis en place un consortium afin de potentialiser des travaux collaboratifs en oncoimmunologie fondamentale et translationnelle des cancers des voies aéro-digestives supérieures (VADS). Ce consortium s’intéresse à la compréhension des interactions entre le stroma tumoral et les cellules immunitaires dans les cancers des VADS afin d’identifier de nouveaux marqueurs pronostiques et de nouvelles approches d’intervention thérapeutique. Dans ce cadre, le consortium recrute un personnel technique, niveau ingénieur ou assistant-ingénieur, en CDD pour une période de 12 mois renouvelables. Le candidat sera chargé de la gestion de biopsies humaines de cancers des VADS dans le cadre de recherches fondamentales et d’essais cliniques d’immunothérapie, de l‘analyse de la signature immunitaire et stromale de ces biopsies humaines par des approches complémentaires d’imagerie en fond clair et de fluorescence et de cytométrie de flux. Ces analyses multiparamétriques requièrent de plus des compétences en informatique et en gestion et archivage de données. More information : 1 poste AI ou ingenieur_Nice

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Poste d’ingénieur-URGENT, CDD 1an

Nous recherchons un ingénieur biologiste motivé(e) pour participer à des recherches sur les mécanismes moléculaires impliqués dans la pathologie du mélanome. Pour identifier ces processus, nous utilisons des approches de biologie cellulaire et moléculaire et génétiques, certaines impliquant des modèles animaux. Formation Master Activités Cultures primaires, transfection (si/shRNA, vecteurs), biologie moléculaire. Western blot, immunofluorescence, PCR quantitative en temps réel, FACS. Analyse bioinformatique. Qualités Motivation et Rigueur au travail indispensables Lieu d’activité  Biologie et Pathologies des mélanocytes, INSERM U1065 (Equipe 1), Centre Méditerranéen de Médecine Moléculaire (C3M), 06204 Nice Cedex. Le poste est à pourvoir de suite. Contact Merci d’envoyer votre CV et une lettre de motivation par email à Robert Ballotti: ballotti@unice.fr

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Ingénieur(e) de recherche en biostatistiques

Lieu de travail : Université François Rabelais, UMR CNRS 7324 CITERES, 33 allée Ferdinand de Lesseps, 37000 Tours. http://citeres.univ-tours.fr Durée : 12 mois, à partir de janvier/février 2018 Contexte et environnement de travail : Unité Mixte de Recherche CITERES mène des recherches sur la thématique « Villes et Territoires ». Rattachée à l’INSHS et à l’INEE du CNRS, son objectif est d’analyser les dynamiques spatiales, environnementales et territoriales des sociétés. Le poste sera intégré dans l’équipe Dynamique et Actions Territoriales et Environnementales (ex IPAPE) qui cherche à approfondir la compréhension des dynamiques du milieu physique et biotique, en particulier pour les hydrosystèmes. Ces travaux s’inscrivent dans les activités de la Zone Atelier Loire dont l’UMR est le gestionnaire. Le recrutement se fait dans le cadre du projet BPO Loire (Biodiversité et variables de forçage dans les habitats de la plaine ligérienne – protocole et outils).). Ce projet a pour objectifs (i) de tester un protocole de suivi scientifique pour plusieurs habitats et taxons de la plaine alluviale de la Loire, (ii) de mieux connaitre les pratiques de suivi et d’analyse de données mises en place par les gestionnaires des milieux naturels et à apporter une aide à des interrogations méthodologiques que certains ont exprimé à l’occasion d’enquêtes, et (iii) de mutualiser les connaissances et résultats des différents suivis entre chercheurs et gestionnaires. Le projet BPO Loire comportera donc la production et l’analyse de données de suivis écologiques complexes qui seront, après valorisation scientifique, mises à disposition de réseaux nationaux et internationaux d’observation Continuer la lecture Ingénieur(e) de recherche en biostatistiques

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